Not so much at the reel but like, Pequod mentioned, the wind will sometimes throw a half hitch around the rod tip if you don't pay attention. Stuff really is like spider web. I've had it hang in the air when lightning was threatening due to static and couldn't make it fall to the water. Was bizarre. The abrasion resistance is something to pay attention to. Need to trim it if it shows any sign of shredding. I like a fluoro or mono leader depending on what I'm doing. Generally use a small swivel or Alberto knot to connect it. Knots are another thing to mention. Nanofil is about the slickest line out there, some knots will slip with it. Certainly has pros and cons but for long casting, shallow water jigging, or bobber fishing, it's hard to beat.
